Related Experiment Video

Updated: Feb 6, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

5.0K

MicroRNAs in diabetic wound healing: Pathophysiology and therapeutic opportunities

Denizhan Ozdemir1, Mark W Feinberg2

  • 1Department of Internal Medicine, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States.

Trends in Cardiovascular Medicine
|August 26, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in diabetic wound healing. Understanding their roles in inflammation, angiogenesis, and remodeling offers therapeutic potential for diabetes mellitus complications.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Endocrinology

Background:

  • Diabetic wound healing is a complex pathophysiological process with severe complications.
  • Diabetes mellitus (DM) leads to impaired healing, infections, and amputations.
  • MicroRNAs (miRNAs) are crucial regulators of cellular processes in health and disease.

Purpose of the Study:

  • To summarize the roles of miRNAs in diabetic wound healing.
  • To highlight miRNA regulation of gene expression and signaling pathways.
  • To explore therapeutic opportunities for diabetic wound complications.

Main Methods:

  • Literature review and synthesis of current evidence on miRNAs in diabetic wound healing.
  • Analysis of miRNA involvement in key healing stages: inflammation, angiogenesis, re-epithelialization, and remodeling.
  • Examination of miRNA-mediated control of gene expression and signaling pathways.

Main Results:

  • miRNAs play versatile roles across all stages of diabetic wound healing.
  • Specific miRNAs influence inflammation, blood vessel formation, and tissue repair.
  • miRNAs fine-tune cellular responses critical for the healing cascade.

Conclusions:

  • miRNAs are significant regulators in diabetic wound healing.
  • Targeting miRNAs presents a promising therapeutic strategy for managing diabetic complications.
  • Further research into miRNA mechanisms can lead to novel treatments for intractable diabetic wounds.
Keywords:
DiabetesWound healingmicroRNAs

More Related Videos

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model08:06

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

11.8K
Author Spotlight: Exploring Corneal Innate Immunity and Delayed Wound Healing in Diabetic Patients03:57

Author Spotlight: Exploring Corneal Innate Immunity and Delayed Wound Healing in Diabetic Patients

Published on: January 10, 2025

24.6K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
3.0K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
963
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.1K