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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
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Small dense LDL cholesterol in human subjects with different chronic inflammatory diseases
D M Schulte1, K Paulsen2, K Türk2
1Department of Internal Medicine I, University of Kiel, Arnold-Heller-Strasse 3, D-24105, Kiel, Germany; Cluster of Excellence Inflammation at Interfaces, University of Kiel, Arnold-Heller-Strasse 3, D-24105, Kiel, Germany.
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|August 26, 2018
Summary
Patients with chronic inflammatory diseases (CID) have higher levels of small-dense LDL (sdLDL) particles, contributing to increased cardiovascular risk. This increased sdLDL may explain the "LDL paradox" observed in CID patients.
Area of Science:
- Cardiology
- Rheumatology
- Immunology
Background:
- Chronic inflammatory diseases (CID) significantly elevate cardiovascular (CV) risk, reducing life expectancy.
- A low LDL-cholesterol level in CID patients is termed the "LDL paradoxon."
Purpose of the Study:
- To investigate if LDL particles in CID patients have an increased content of small-dense LDL (sdLDL), a highly atherogenic subfraction.
Main Methods:
- A prospective, single-center observational study included 141 CID patients (RA, IBD, SpA, Psoriasis).
- sdLDL levels were assessed before and 6, 26 weeks after anti-cytokine therapy initiation.
- sdLDL levels were compared to 141 healthy controls in a case-control design.
Main Results:
- All CID patient groups showed significantly higher sdLDL content compared to healthy controls.
- Specific increases noted in Rheumatoid Arthritis (RA) (35.0±9.2%), Spondyloarthritis (SpA) (42.5±10.5%), Inflammatory Bowel Disease (IBD) (37.5±7.1%), and Psoriasis (33.6±4.6%).
- Anti-cytokine therapies (anti-TNFα, anti-IL-6R) did not alter sdLDL levels despite improving disease activity.
Conclusions:
- LDL-cholesterol shifts towards a pro-atherogenic phenotype in CID due to increased sdLDL, potentially explaining the "LDL paradoxon."
- Targeting lipid metabolism is crucial for managing premature cardiovascular disease in CID patients.
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