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Updated: Feb 6, 2026

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
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Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A

Nguyen Thanh Liem1, Vu Duy Chinh2, Nguyen Thi Thinh3

  • 1Stem Cell and Immune Cell Department, Vinmec Research Institute of Stem Cell and Gene Technology, Times City, Ha Noi, Vietnam.

The American Journal of Case Reports
|August 26, 2018
PubMed

Insights

Bone marrow-derived mononuclear cells transplantation improved bowel function in two children with spina bifida. This novel treatment offers hope for managing bowel dysfunction in spina bifida patients.

Area of Science:

  • Regenerative Medicine
  • Pediatric Gastroenterology
  • Spinal Cord Injury Research

Background:

  • Spina bifida frequently causes bowel dysfunction, affecting over 70% of patients.
  • Conventional treatments for neurogenic bowel dysfunction in spina bifida often provide limited efficacy.
  • Myelomeningocele repair is a common intervention, but bowel dysfunction persists post-surgery.

Observation:

  • Two pediatric patients with spina bifida and severe bowel dysfunction post-myelomeningocele repair were treated.
  • Bone marrow-derived mononuclear cells (BMMNC) transplantation was administered to both patients without complications.
  • Follow-up periods extended to 21 months for one patient and 16 months for the other.

Findings:

  • Both patients demonstrated significant improvement in bowel function post-BMMNC transplantation.
  • Normal defecation was achieved and sustained in the treated pediatric patients.
  • The study highlights a potential therapeutic benefit of BMMNC transplantation for bowel dysfunction.

Implications:

  • BMMNC transplantation presents a promising therapeutic avenue for improving bowel function in spina bifida.
  • This approach may offer a novel solution for refractory neurogenic bowel dysfunction.
  • Further research into BMMNC transplantation could advance treatment strategies for pediatric patients with spina bifida.

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