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[Lactic acidosis].

G M Molinatti, P Passera, P Schimenti

    Minerva Medica
    |June 23, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Lactic acidosis (LA) is a metabolic issue from increased lactate. Treatment involves addressing causes, correcting acidosis, and removing excess lactate.

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    Area of Science:

    • Biochemistry
    • Metabolic Disorders

    Background:

    • Lactic acidosis (LA) is a metabolic disturbance involving an increased lactate production/clearance ratio.
    • Lactate, a glycolysis catabolite, accumulates under anaerobic conditions.
    • Clinical LA is defined by acidosis signs, venous lactate > 5 mMol/L, and arterial pH < 7.25.

    Purpose of the Study:

    • To outline the classification and clinical characteristics of lactic acidosis.
    • To highlight the significance of LA in type II diabetes mellitus patients treated with phenformin.
    • To review current therapeutic strategies for managing lactic acidosis.

    Main Methods:

    • Review of metabolic pathways and clinical definitions of lactic acidosis.
    • Classification of LA into Type A (shock-induced) and Type B (pathology, exogenous substances, metabolic diseases).

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  • Discussion of phenformin's role in LA for type II diabetes mellitus.

    • Main Results:

    • LA is characterized by specific biochemical and clinical markers.
    • Type B LA has diverse etiologies, including drug-induced and inherited metabolic conditions.
    • Phenformin use in type II diabetes mellitus is a notable risk factor for LA.

    Conclusions:

    • Effective LA management requires addressing the underlying cause of lactate overproduction.
    • Correction of acidosis with alkalinizing solutions is a key therapeutic step.
    • Pharmacological removal or dialysis may be necessary to manage excess lactate levels.