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Related Experiment Video

Updated: Feb 6, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

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Published on: March 1, 2016

Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions.

Benjamin J Sieniewicz^1,2, Justin Gould^3,4, Bradley Porter^3,4

¹Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor, North Wing, St Thomas' Hospital, London, SE1 7EH, UK. benjamin.sieniewicz@kcl.ac.uk.

Heart Failure Reviews

|August 26, 2018

Summary

Cardiac resynchronisation therapy (CRT) helps heart failure patients, but many don't respond. Endocardial pacing, stimulating the left ventricle from within, shows promise for improving CRT response rates.

Keywords:

CRT Endocardial pacing Heart failure Non-responders

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Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Area of Science:

Cardiology
Medical Devices
Heart Failure Research

Background:

Heart failure presents a significant burden of morbidity and mortality.
Reduced left ventricular (LV) function can lead to dyssynchronous activation, a target for cardiac resynchronisation therapy (CRT).
A substantial proportion of patients (30-50%) do not benefit from conventional CRT.

Purpose of the Study:

To explore alternative methods for CRT delivery to improve patient response rates.
To evaluate the potential of endocardial pacing as a novel CRT strategy.

Main Methods:

Review of factors contributing to CRT non-response.
Investigation of technical limitations of traditional transvenous epicardial CRT.
Assessment of endocardial pacing as an alternative LV stimulation method.

Main Results:

Non-response to CRT is multifactorial, influenced by pre-, peri-, and post-implant factors.
Technical challenges with traditional CRT delivery impact efficacy.
Endocardial pacing emerges as a promising alternative approach.

Conclusions:

Novel methods for CRT delivery are needed to overcome limitations of current therapies.
Endocardial pacing offers a potentially more effective strategy for CRT in non-responders.
Further research into endocardial pacing is warranted to optimize heart failure treatment.