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Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
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Tissue-engineering approaches in pancreatic islet transplantation
Marcos Perez-Basterrechea1,2, Manuel M Esteban3, Jose A Vega4,5
1Unidad de Terapia Celular y Medicina Regenerativa, Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Biotechnology and Bioengineering
|August 26, 2018
Summary
Pancreatic islet transplantation offers a promising treatment for type 1 diabetes mellitus by improving islet survival and function. Researchers are exploring tissue engineering strategies to minimize immune rejection and enhance transplant success.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Transplantation Immunology
Background:
- Type 1 diabetes mellitus (T1DM) management remains a challenge.
- Pancreatic islet transplantation is an alternative to whole-pancreas transplantation.
- Standard transplantation protocols face complications and immune rejection.
Purpose of the Study:
- To review and discuss strategies for pancreatic islet transplantation.
- To improve islet survival and functionality post-transplantation.
- To reduce host immune response and achieve normoglycemic control.
Main Methods:
- Utilizing tissue engineering and regenerative medicine approaches.
- Employing various scaffolds, cell types, and diffusible factors.
- Investigating strategies to minimize immune response and enhance islet survival.
Main Results:
- Pancreatic islet transplantation has shown variable outcomes in terms of survival and function.
- Successful islet engraftment and normoglycemic control have been achieved in some patients.
- Ongoing research focuses on optimizing strategies for consistent success.
Conclusions:
- Pancreatic islet transplantation is a viable strategy for T1DM treatment.
- Tissue engineering and regenerative medicine offer promising avenues for improving outcomes.
- Further research is needed to overcome immune barriers and ensure long-term islet survival and function.
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