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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

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Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
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Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...

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Related Experiment Video

Updated: Feb 6, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long non-coding RNA CASC2 in solid tumors: A meta-analysis.

Chaojie Liang¹, Jinghong Zhang¹, Hua Ge¹

¹Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|August 26, 2018

Summary

This meta-analysis found that low expression of cancer susceptibility 2 (CASC2) is linked to advanced cancer characteristics. Higher CASC2 levels correlate with better patient survival, suggesting CASC2 as a potential cancer biomarker.

Keywords:

LncRNA CASC2 Meta-analysis Neoplasm Prognosis

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Last Updated: Feb 6, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Long non-coding RNA cancer susceptibility 2 (CASC2) is frequently downregulated in human solid tumors.
Previous studies had limited sample sizes, leaving the role of CASC2 in cancer unclear.

Purpose of the Study:

To conduct a meta-analysis to explore the role of CASC2 in solid tumors.
To investigate the association between CASC2 expression and clinicopathological characteristics and prognosis of cancer patients.

Main Methods:

Systematic literature search across multiple databases (PubMed, Medline, Web of Science, EMBASE, etc.).
Meta-analysis of 15 studies involving 1158 patients.
Analysis of The Cancer Genome Atlas (TCGA) dataset for CASC2 expression.

Main Results:

Low CASC2 expression correlated with larger tumor size, lower differentiation, and advanced TNM stage.
High CASC2 expression was associated with improved overall survival (OS) and disease-free survival (DFS).
CASC2 was identified as an independent predictive factor for OS.

Conclusions:

Reduced CASC2 expression is linked to unfavorable clinicopathological features in human cancers.
CASC2 shows potential as a prognostic biomarker for cancer.
Further research is recommended to validate these findings.