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Long non-coding RNA CASC2 in solid tumors: A meta-analysis

Chaojie Liang1, Jinghong Zhang1, Hua Ge1

  • 1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 26, 2018
PubMed
Abstract

Insights

This meta-analysis found that low expression of cancer susceptibility 2 (CASC2) is linked to advanced cancer characteristics. Higher CASC2 levels correlate with better patient survival, suggesting CASC2 as a potential cancer biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNA cancer susceptibility 2 (CASC2) is frequently downregulated in human solid tumors.
  • Previous studies had limited sample sizes, leaving the role of CASC2 in cancer unclear.

Purpose of the Study:

  • To conduct a meta-analysis to explore the role of CASC2 in solid tumors.
  • To investigate the association between CASC2 expression and clinicopathological characteristics and prognosis of cancer patients.

Main Methods:

  • Systematic literature search across multiple databases (PubMed, Medline, Web of Science, EMBASE, etc.).
  • Meta-analysis of 15 studies involving 1158 patients.
  • Analysis of The Cancer Genome Atlas (TCGA) dataset for CASC2 expression.

Main Results:

  • Low CASC2 expression correlated with larger tumor size, lower differentiation, and advanced TNM stage.
  • High CASC2 expression was associated with improved overall survival (OS) and disease-free survival (DFS).
  • CASC2 was identified as an independent predictive factor for OS.

Conclusions:

  • Reduced CASC2 expression is linked to unfavorable clinicopathological features in human cancers.
  • CASC2 shows potential as a prognostic biomarker for cancer.
  • Further research is recommended to validate these findings.
Keywords:
LncRNA CASC2Meta-analysisNeoplasmPrognosis

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