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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Scaling code-multiplexed electrode networks for distributed Coulter detection in microfluidics.

Ruxiu Liu1, Ningquan Wang1, Norh Asmare1

  • 1School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States.

Biosensors & Bioelectronics
|August 26, 2018
PubMed
Summary
This summary is machine-generated.

This study scales microfluidic devices for particle detection using a novel multiplexed sensing technique. The developed code-multiplexed Coulter sensor network enables efficient, distributed analysis of biological samples like cancer cells.

Keywords:
CDMACodingCoulter sensingMicrofluidicsMultiplexingSensor network

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Sensor Technology

Background:

  • Microfluidic devices offer particle discrimination and spatial mapping.
  • Distributed detection requires advanced sensing techniques.

Purpose of the Study:

  • To investigate the scalability of code-multiplexed Coulter sensor networks.
  • To optimize microfluidic devices for enhanced particle detection.

Main Methods:

  • Fabrication of a 10-sensor microfluidic device with unique digital codes.
  • Development of a mathematical model using communications and coding theory.
  • Theoretical and experimental analysis of electrical impedance and signal-to-noise ratio.

Main Results:

  • Verified 31-bit orthogonal digital codes for each sensor.
  • Developed an optimized device and a computational data processing approach.
  • Demonstrated system-level operation with cultured human cancer cells.

Conclusions:

  • Large-scale code-multiplexed electrode networks are feasible for distributed Coulter detection.
  • This technique supports the development of integrated lab-on-a-chip devices.
  • The system enables efficient, user-minimal data processing for biological samples.