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Current clinical trials in paediatrics: Report of the ESPEN special interest group in paediatrics

R D Eveleens1, K Gerasimidis2, M Chourdakis3

  • 1Department of Pediatrics and Pediatric Surgery, Intensive Care Unit, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.

Clinical Nutrition ESPEN
|August 27, 2018
PubMed

Insights

This study analyzed 430 pediatric nutrition trials, finding most focus on specific diseases and obesity. Future research should prioritize well-controlled interventional studies in children

Area of Science:

  • Pediatric Nutrition Research
  • Clinical Trials in Children
  • Global Health Studies

Background:

  • The Special Interest Group (SIG) in Paediatrics presented current global research activities in pediatric nutrition at the 38th annual ESPEN congress.
  • The presentation aimed to identify future research perspectives in the field of pediatric nutrition.

Purpose of the Study:

  • To analyze the landscape of registered clinical nutrition trials in pediatrics worldwide.
  • To identify key research areas and trends in pediatric nutrition.
  • To provide recommendations for future research directions.

Main Methods:

  • Conducted an extensive search of ClinicalTrials.gov for observational and interventional trials.
  • Utilized search terms: "children nutrition," "paediatrics nutrition," and "children feeding."
  • Analyzed 430 relevant trials after excluding duplicates and adult studies.

Main Results:

  • A total of 430 pediatric nutrition trials were identified, with 69% being randomized controlled trials.
  • The most researched topics were nutrition in specific diseases (98 studies) and obesity (92 studies), followed by premature infant nutrition (48 studies).
  • The median estimated enrollment was 150 children per trial, with large-scale studies (>1000 participants) concentrated in North America, Africa, and Europe.

Conclusions:

  • Current pediatric nutrition research is dominated by trials focusing on specific diseases and obesity.
  • The SIG Paediatrics advocates for increased investment in well-controlled interventional trials in pediatric nutrition.
  • Further research is encouraged to address critical gaps and advance the field of pediatric nutrition.
Abstract

Keywords:
Clinical trialsNutritionPaediatricsSpecial interest group

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