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[Parvovirus B 19].

J J Lefrere, A M Courouce, J P Soulier

    Presse Medicale (Paris, France : 1983)
    |April 12, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Human parvovirus B19 causes temporary severe anemia (erythroblastopenia) in individuals with chronic hemolytic anemia. It may also cause Fifth Disease (erythema infectiosum) in children.

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    Area of Science:

    • Virology
    • Hematology
    • Immunology

    Background:

    • Human parvovirus B19, identified in blood donors, is linked to erythroblastopenia in chronic hemolytic anemia patients.
    • In vitro studies show parvovirus B19 inhibits erythroid precursors, an effect reversed by convalescent serum.

    Purpose of the Study:

    • To establish parvovirus B19 as the causative agent of transient erythroblastopenia in chronic hemolytic anemia.
    • To investigate the role of parvovirus B19 in erythema infectiosum.

    Main Methods:

    • In vitro cultures of erythroid inhibitors.
    • Analysis of clinical reports linking parvovirus B19 to specific conditions.

    Main Results:

    • Parvovirus B19 demonstrated inhibitory effects on erythroid precursors in vitro.

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  • In healthy individuals, parvovirus B19 infection can cause an influenza-like illness with transient erythroblastopenia.
  • Parvovirus B19 is implicated as the cause of erythema infectiosum (fifth disease).

    • Conclusions:

    • Parvovirus B19 is a significant cause of transient erythroblastopenia in patients with chronic hemolytic anemia.
    • Parvovirus B19 is a suspected causative agent of erythema infectiosum in children.