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Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis

Huifang Zhu1, Fei Wang2, Xiaoman Ju1

  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; University of Chinese Academy of Sciences, Beijing, PR China.

Biochemical and Biophysical Research Communications
|August 27, 2018
PubMed

Insights

Aurovertin B, a natural compound, enhances cancer cell recognition and destruction by natural killer (NK) cells. This compound boosts NKG2D ligand expression on tumor cells, making them more susceptible to NK cell-mediated killing, suggesting its potential in cancer immunotherapy.

Area of Science:

  • Immunology
  • Natural Products Chemistry
  • Cancer Research

Background:

  • Natural killer (NK) cells are crucial for immunosurveillance against cancer.
  • The NKG2D receptor on NK cells mediates tumor cell recognition and lysis via interactions with NKG2D ligands on cancer cells.

Purpose of the Study:

  • To investigate the effect of the natural compound aurovertin B on NK cell-mediated cancer cell cytotoxicity.
  • To explore a novel role for aurovertin B in cancer immunotherapy.

Main Methods:

  • Treatment of tumor cells with aurovertin B.
  • Assessment of NKG2D ligand expression on tumor cells.
  • Evaluation of NK cell-mediated tumor cell recognition and lysis.

Main Results:

  • Aurovertin B significantly stimulates the expression of NKG2D ligands on tumor cells.
  • This stimulation enhances the recognition and lysis of tumor cells by NK cells.
  • Aurovertin B demonstrates a novel mechanism for targeting tumor cells for NK cell-mediated destruction.

Conclusions:

  • Aurovertin B acts as a sensitizing agent, improving NK cell-mediated cancer cell killing.
  • Aurovertin B holds promise for further development as an adjuvant therapy in NK cell-based cancer immunotherapy.
Keywords:
Aurovertin BCytotoxicityImmunotherapyNK cellNKG2D ligands

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