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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: Advancing Syphilis Research &#8212; Innovations in Treponema pallidum Cultivation and Genetic Engineering
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Serological evolution in early syphilis.

Maider Arando1, Miriam Mota-Foix2, Pere Armegol3

  • 1Unidad de ITS Vall d'Hebron-Drassanes, Servicio Infeccioses, Hospital Vall d'Hebron, Barcelona, España; Departamento de Medicina, Universidad Autónoma de Barcelona, Barcelona, España.

Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|August 27, 2018
PubMed
Summary

HIV status does not impact syphilis treatment outcomes. Early syphilis patients, regardless of HIV status, achieve serological cure within approximately 3 months following recommended treatment protocols.

Keywords:
Early syphilisEvolución serológicaHuman immunodeficiency virusSerological evolutionSífilis precozVirus de la inmunodeficiencia humana

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Area of Science:

  • Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • Syphilis treatment evolution can be influenced by factors such as Human Immunodeficiency Virus (HIV) co-infection.
  • HIV-positive individuals with syphilis may require adjusted treatment regimens, including higher doses of penicillin (PBG).

Purpose of the Study:

  • To describe and compare the serological evolution of early syphilis in patients in Barcelona.
  • To identify factors influencing treatment outcomes in early syphilis, with a focus on HIV status.

Main Methods:

  • Serological follow-up was conducted over one year for 208 patients diagnosed with early syphilis.
  • Time-to-cure analysis utilized Kaplan-Meier curves to assess serological evolution.

Main Results:

  • The median time to serological cure was 99 days (95% CI: 97-105), with no significant differences observed based on HIV status, prior syphilis history, disease stage, or initial RPR titers.
  • A trend towards better serological evolution was noted in patients treated with doxycycline (P=.02).

Conclusions:

  • Serological evolution and treatment outcomes for early syphilis are comparable between HIV-negative and HIV-positive patients when treated according to current guidelines.
  • The study confirms that serological cure is typically achieved within three months post-treatment for early syphilis.