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Related Experiment Video

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Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain

Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain

Published on: October 24, 2017

Association between protein profile and postmortem interval in human bone remains.

Gemma Prieto-Bonete¹, María D Pérez-Cárceles¹, Antonio Maurandi-López²

¹Department of Legal and Forensic Medicine, University of Murcia, Spain.

Journal of Proteomics

|August 27, 2018

Summary

This summary is machine-generated.

Forensic proteomic analysis of human bone can estimate the late postmortem interval (PMI). Specific protein profiles in bones help approximate the time of death between 5 and 20 years, aiding forensic investigations.

Keywords:

Bone remain Forensic science Postmortem interval Protein profile Proteomic

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Area of Science:

Forensic science
Biochemistry
Osteology

Background:

Estimating the postmortem interval (PMI) is crucial in forensic science.
Current PMI estimation methods are often limited for decomposed samples, especially osseous remains.
There is a need for reliable techniques to determine PMI in later stages.

Purpose of the Study:

To investigate the potential of bone protein profiles for estimating a late postmortem interval (PMI).
To determine if specific proteins in human bone can differentiate between timeframes of 5 to 20 years postmortem.

Main Methods:

Proteomic analysis was performed on 40 human femur bones with known postmortem intervals (5-20 years).
Proteins were identified and quantified, excluding circulating proteins.
A multiple correspondence analysis was used to identify discriminating protein profiles.

Main Results:

A total of 48 bone proteins (29 structural, 19 functional) were identified after excluding circulating proteins.
Analysis identified 32 key proteins capable of discriminating between different postmortem intervals.
The identified protein profile allowed for the approximation of death dates within the 5-20 year range.

Conclusions:

Bone protein profiles can be utilized to estimate late postmortem intervals.
This proteomic approach offers a complementary method for PMI estimation in forensic investigations.
The findings suggest a novel application of proteomics in determining the time since death for skeletal remains.