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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
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Updated: Feb 6, 2026

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Telemedicine: a Primer.

Morgan Waller1, Chad Stotler2

  • 1Department of Medical Informatics and Telemedicine, Children's Mercy, Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.

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|August 27, 2018
PubMed
Summary
This summary is machine-generated.

Telemedicine is rapidly advancing due to technology and internet improvements, becoming a standard in healthcare. This review covers its definition, benefits, and implementation strategies for healthcare professionals.

Keywords:
ContractsCredentialsLegalLicensureOperationsRegulatoryReimbursementTelemedicineTraining

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Area of Science:

  • Digital Health
  • Healthcare Technology
  • Telehealth Innovation

Background:

  • Rapid advancements in interactive technologies and internet infrastructure are accelerating the adoption of telemedicine.
  • Industry projections indicate significant growth in the telemedicine market, with valuations expected to exceed 20 billion US dollars.
  • Leading healthcare institutions like the Mayo Clinic are centralizing telemedicine operations for efficiency and standardization.

Purpose of the Study:

  • To provide an expert overview of telemedicine, including its definition and benefits.
  • To guide healthcare providers on the advantages of practicing telemedicine.
  • To offer insights into the implementation of telemedicine services.

Main Methods:

  • Expert opinion synthesis.
  • Review of current research findings on telemedicine.
  • Analysis of industry trends and patient satisfaction data.

Main Results:

  • Telemedicine is transitioning from a novel concept to an established healthcare delivery model.
  • Patient satisfaction with telemedicine services is consistently high, accepted as a industry fact.
  • Significant growth is projected for the telemedicine sector, driven by technological and infrastructural advancements.

Conclusions:

  • Telemedicine is a rapidly evolving field necessitating a clear understanding of its scope and benefits.
  • Healthcare organizations should strategically approach telemedicine implementation for optimal integration.
  • The widespread acceptance and proven patient satisfaction underscore the importance of telemedicine in modern healthcare.