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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

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Cardiac diastolic dysfunction predicts poor prognosis in patients with decompensated liver cirrhosis

Soon Kyu Lee1, Myeong Jun Song1, Seok Hwan Kim1

  • 1Division of Hepatology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.

Clinical and Molecular Hepatology
|August 28, 2018
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) significantly reduces survival in liver cirrhosis (LC) patients. Monitoring LVDD is crucial for improving outcomes in decompensated liver disease.

Area of Science:

  • Cardiology
  • Hepatology
  • Echocardiography

Background:

  • Left ventricular diastolic dysfunction (LVDD) is an early cardiac issue in liver cirrhosis (LC).
  • The impact of LVDD on survival, particularly in decompensated LC, remains unclear.

Purpose of the Study:

  • To investigate the association between LVDD and overall survival in patients with decompensated liver cirrhosis.

Main Methods:

  • Prospective enrollment of 70 decompensated LC patients.
  • Cardiac function assessed via 2D echocardiography with tissue Doppler imaging.
  • LVDD diagnosis based on American Society of Echocardiography guidelines; primary endpoint was overall survival.

Main Results:

  • 62.9% of patients had LVDD.
  • LVDD was associated with significantly lower survival rates (31.1 months vs. 42.6 months, P=0.01).
  • LVDD and Child-Pugh score were independent predictors of survival; higher E/e' ratio indicated poorer survival.

Conclusions:

  • LVDD presence is linked to poor survival in decompensated LC patients.
  • Monitoring LVDD in these patients is important for clinical management.
Abstract

Keywords:
CardiomyopathiesDiastolic heart failureEchocardiographyLiver cirrhosis

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