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Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in

Olatunde P Olabode1,2, Olawale M Akinlade2,3, Abiola S Babatunde4

  • 1HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

Archives of Physiology and Biochemistry
|August 28, 2018
PubMed

Insights

The triglyceride to HDL cholesterol ratio (TG/HDL-C) and plasminogen activator inhibitor-1 (PAI-1) are linked to high pulse pressure in sickle cell trait and disease patients. These factors may indicate risks for arterial stiffness and cardiovascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • Sickle cell trait (SCT) and sickle cell disease (SCD) are genetic blood disorders.
  • Arterial stiffness and cardiovascular disease (CVD) are potential complications.
  • Pulse pressure (PP) is an indicator of arterial stiffness.

Purpose of the Study:

  • To investigate the association between TG/HDL-C ratio, PAI-1, and high pulse pressure (PP) in young adults with SCT and SCD.
  • To compare cardiometabolic parameters across different sickle cell genotypes.

Main Methods:

  • Cross-sectional study comparing individuals with normal genotype (HbAA), SCT (HbAS), and SCD (HbSS) in steady state (n=60 each).
  • Multivariate linear regression analysis to assess relationships between biochemical markers and PP.
  • Receiver operating characteristic (ROC) curve analysis to evaluate predictive efficiency.

Main Results:

  • High PP was positively associated with TG/HDL-C ratio in SCT individuals (β=0.307, p=0.014).
  • High PP was positively associated with PAI-1 in SCD individuals (β=0.499, p=0.001).
  • TG/HDL-C ratio and PAI-1 demonstrated efficient predictive value for high PP in SCT and SCD, respectively.

Conclusions:

  • Elevated TG/HDL-C ratio and PAI-1 levels are potential risk factors for arterial stiffness and CVD in SCT carriers and SCD patients.
  • These biochemical markers may aid in identifying individuals at higher risk within these populations.

Keywords:
Plasminogen activator inhibitor-1pulse pressuresickle cell diseasesickle cell traittriglyceride/high-density lipoprotein ratio

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