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Related Experiment Video

Updated: Feb 6, 2026

Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft
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Nerve growth factor continuously elevates in a rat rotator cuff tear model.

Naoshige Nagura1, Tomonori Kenmoku1, Kentaro Uchida1

  • 1Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Journal of Shoulder and Elbow Surgery
|August 28, 2018
PubMed
Summary

Nerve growth factor (NGF) is elevated in rotator cuff tears (RCT), driven by tumor necrosis factor-alpha (TNF-α). This suggests NGF could be a therapeutic target for RCT pain.

Keywords:
COX-2Rotator cuff tearinterleukin (IL)-1βnerve growth factorpaintumor necrosis factor-α

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Area of Science:

  • Orthopedics
  • Pain Management
  • Molecular Biology

Background:

  • Nerve growth factor (NGF) is implicated in osteoarthritic and low back pain.
  • Rotator cuff tear (RCT) causes significant shoulder pain, but NGF's role is unclear.

Purpose of the Study:

  • To investigate the role and regulation of NGF in rotator cuff tears (RCT).

Main Methods:

  • Compared gene expression (Tnfa, Ngf, Il1b, Cox2) and protein levels of NGF in sham and RCT rat models.
  • Utilized RT-PCR, ELISA, and immunohistochemistry.
  • Stimulated rotator cuff cells with TNF-α to assess NGF regulation.

Main Results:

  • NGF and TNF-α (Tnfa) mRNA levels were upregulated in RCT rats for up to 56 days.
  • Elevated NGF protein levels were observed in RCT groups at 1 and 14 days post-surgery.
  • TNF-α stimulation increased Ngf mRNA expression in rotator cuff cells.

Conclusions:

  • NGF is continuously elevated in RCT, primarily regulated by TNF-α.
  • NGF presents a potential therapeutic target for managing rotator cuff tear pain.