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Updated: Feb 6, 2026

Understanding Cerebellar Pattern Formation
Published on: November 1, 2007
An unusual presentation of cerebellar lymphoma
Benjamin Harley1, Ganeshwaran Shivapathasundram1, Arnar Astradsson2
1Department of Neurosurgery, Wellington Hospital, Wellington, New Zealand.
Abstract:
We report a case of a 40 year old female who presented with a three month history of headaches with a background of Myasthenia Gravis (MG), treated with azathioprine. MRI brain demonstrated a rim-enhancing lesion in the left posterior fossa. CT scan of the chest abdomen and pelvis revealed no other lesion. The patient was taken for resection of the lesion via left retrosigmoid approach. Histologically the neoplasm was a large B-cell lymphoma, Epstein-Barr virus (EBV) positive, with clonality confirmed by IGH gene rearrangement studies. To the best of our knowledge this is the first case of primary central nervous system (CNS) EBV-positive diffuse large B-cell lymphoma of the posterior fossa in a patient with MG treated with azathioprine.
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