Murine thymocytes mediate a natural killer-like activity against herpes virus-infected target cells but not YAC-1...

In this report, we demonstrated a natural killer (NK)-like activity against HSV-1 infected cells mediated by CD-1 mouse thymocytes. This cytolytic activity is specific for HSV-1-infected MCN cells, since both uninfected MCN and YAC-1 target cells are not susceptible to thymocyte lysis. Antibody plus complement depletion experiments indicate that a portion of the activity is associated with the Lyt 2-/L3T4- thymocyte subpopulation. This NK-like activity cannot be enhanced by addition of interleukin 2 in vitro.