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Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
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Fentanyl: A Whole New World?

Rachel L Rothberg1, Kate Stith1

  • 1Rachel L. Rothberg received her B.A. from Yale College and will receive her J.D. from Yale Law School in May 2019. Kate Stith, J.D., M.P.P., is the Lafayette S. Foster Professor of Law at Yale Law School. She received her B.A. from Dartmouth College, and her M.P.P. and J.D. from Harvard University.

The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics
|August 28, 2018
PubMed
Summary

Fentanyl, a synthetic opioid 50x more potent than heroin, is rapidly increasing in the illicit drug market. Its low manufacturing cost and easy distribution contribute to the escalating opioid crisis.

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Introduction.

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics·2018
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The Role of Civil Commitment in the Opioid Crisis.

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics·2018
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Buprenorphine MAT as an Imperfect Fix.

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics·2018
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The Opioid Crisis and Federal Criminal Prosecution.

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics·2018

Area of Science:

  • Pharmacology
  • Toxicology
  • Public Health

Background:

  • The opioid crisis remains a significant public health concern.
  • Emergence of novel synthetic opioids presents new challenges.

Purpose of the Study:

  • To document the increasing prevalence and danger of fentanyl and related synthetic opioids.
  • To highlight fentanyl's characteristics contributing to its widespread illicit use.

Main Methods:

  • Literature review and analysis of available data on synthetic opioid trends.
  • Examination of fentanyl's chemical properties and manufacturing processes.
  • Assessment of distribution channels and market penetration.

Main Results:

  • Fentanyl is approximately 50 times more potent than heroin.

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  • Illicit fentanyl is cheaper to produce in laboratories globally.
  • Fentanyl is readily distributed through mail and courier services, rapidly entering national markets.

    • Conclusions:

    • Fentanyl represents a critical and escalating danger in the ongoing opioid crisis.
    • Its potency, low cost, and ease of distribution facilitate its dominance in illicit opioid markets.