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MiRNAs: Biology, Biogenesis, their Web-based Tools, and Databases.

Majid Tafrihi1, Elham Hasheminasab1

  • 1Molecular & Cell Biology Research Lab. 2, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.

Microrna (Shariqah, United Arab Emirates)
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This paper reviews microRNA (miRNA) databases and web tools, offering a centralized resource for researchers. It categorizes these tools to facilitate efficient access to crucial miRNA data for various biological studies.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • MicroRNAs (miRNAs) are endogenous non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNA biogenesis occurs in the nucleus, followed by RISC complex assembly in the cytoplasm.
  • miRNAs are involved in diverse biological processes including development, metabolism, and cell death.

Purpose of the Study:

  • To compile and introduce available miRNA databases and web-based tools.
  • To provide researchers with efficient access to miRNA-related data.
  • To categorize existing miRNA resources for improved usability.

Main Methods:

  • Literature review and data compilation of existing miRNA databases and tools.
  • Categorization of resources based on content (e.g., viral, plant, human, disease-related, target prediction, expression).
  • Inclusion of statistical information for each database.

Main Results:

  • A comprehensive collection of miRNA databases and web tools is presented.
  • Databases are categorized into distinct classes for targeted research.
  • Statistical data on database scope and content are provided.

Conclusions:

  • Centralized miRNA databases and tools enhance research efficiency.
  • Categorization aids researchers in finding specific, relevant miRNA information.
  • This review serves as a valuable guide to available miRNA bioinformatics resources.