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The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer

Jinyun Li1, Shumin Ni1, Chongchang Zhou2

  • 1Department of Oncology and Hematology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China, yemeng@nbu.edu.cn.

Cancer Management and Research
|August 28, 2018
PubMed
Abstract

Insights

Circular RNAs (circRNAs) are increasingly important in cancer. This study found hsa_circ_0000711 is downregulated in colorectal cancer (CRC) and may serve as a diagnostic and prognostic biomarker.

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs with emerging roles in cancer.
  • Their specific functions and clinical relevance in colorectal cancer (CRC) are largely unknown.

Purpose of the Study:

  • To investigate the expression pattern and clinical significance of hsa_circ_0000711 in colorectal cancer (CRC).
  • To evaluate hsa_circ_0000711 as a potential diagnostic and prognostic biomarker for CRC.

Main Methods:

  • Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure hsa_circ_0000711 expression.
  • Expression levels were analyzed in 101 paired CRC tissues and 3 CRC cell lines compared to normal controls.

Main Results:

  • hsa_circ_0000711 expression was significantly downregulated in CRC tissues and cell lines (P<0.01).
  • The receiver characteristic curve analysis showed an area of 0.81, with 0.91 sensitivity and 0.58 specificity.
  • Low hsa_circ_0000711 expression independently predicted poor overall survival in CRC patients (HR=2.409, P=0.004).

Conclusions:

  • hsa_circ_0000711 may play a role in colorectal cancer (CRC) development.
  • hsa_circ_0000711 shows potential as an effective biomarker for CRC diagnosis and prognosis.
Keywords:
CRCbiomarkercircular RNAsdiagnosisprognosis

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