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Dissection and Staining of Drosophila Larval Ovaries
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Androgen Action in the Ovary.

Stephen Franks1, Kate Hardy1

  • 1Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom.

Frontiers in Endocrinology
|August 28, 2018
PubMed
Summary

Ovarian androgens are crucial for follicle development and ovulation. This study explores their role in normal follicle maturation and abnormalities seen in polycystic ovary syndrome (PCOS).

Keywords:
androgen receptorapoptosisfollicle atresiafollicle developmentgenomic and non-genomic actionspolycystic ovary syndrome

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Area of Science:

  • Reproductive Endocrinology
  • Ovarian Physiology
  • Cellular Signaling

Background:

  • Ovarian androgen production is vital for estradiol secretion and follicular development.
  • Androgens influence granulosa cell proliferation and apoptosis, potentially ensuring mono-follicular ovulation in primates.
  • Understanding androgen signaling, including genomic and non-genomic effects, is key to reproductive health.

Purpose of the Study:

  • To elucidate the physiological role of ovarian androgens in normal follicle development and maturation.
  • To investigate the contribution of local androgen action to aberrant follicle development in polycystic ovary syndrome (PCOS).
  • To review the role of androgens in follicle atresia.

Main Methods:

  • Review of existing literature on ovarian androgen production and signaling.
  • Analysis of evidence linking local androgens to follicular abnormalities in PCOS.
  • Examination of the role of androgens in the process of follicle atresia.

Main Results:

  • Androgens are essential for preantral and antral follicle development, promoting granulosa cell proliferation.
  • In mature antral follicles, androgens may induce apoptosis, contributing to follicle atresia and mono-follicular ovulation.
  • Evidence suggests local androgen action contributes to aberrant follicle development in PCOS.

Conclusions:

  • Ovarian androgens play a critical role in normal follicle maturation, including atresia.
  • Aberrant androgen signaling is implicated in the follicular dysregulation observed in PCOS.
  • The multifaceted actions of androgens are integral to ovarian physiology.