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Updated: Feb 6, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
The EndoBarrier: Duodenal-Jejunal Bypass Liner for Diabetes and Weight Loss
Aruchuna Ruban1, Hutan Ashrafian1, Julian P Teare1
1Department of Surgery and Cancer, Imperial College, London, UK.
Abstract:
The rapid rise of obesity and type 2 diabetes poses a global threat to healthcare and is a major cause of mortality and morbidity. Bariatric surgery has revolutionised the treatment of both these conditions but is invasive and associated with an increased risk of complications. The EndoBarrier is a device placed endoscopically in the duodenum, which is designed to mimic the effects of gastric bypass surgery with the aim of inducing weight loss and improving glycaemic control. This review outlines the current clinical evidence of the device, its efficacy, potential mechanisms of action, and utility in clinical practice.
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