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Etiological Profile of Galactorrhoea
Sridevi Atluri1, Vijaya Sarathi1, Amit Goel1
1Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India.
Indian Journal of Endocrinology and Metabolism
|August 28, 2018
Summary
Prokinetic medications are the leading cause of galactorrhea and hyperprolactinemia in women. Increased awareness and reduced non-specific prokinetic use are needed to avoid unnecessary tests and treatments for drug-induced galactorrhea.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Non-specific prokinetic use is increasing.
- This may alter the causes of hyperprolactinemia and galactorrhea.
Purpose of the Study:
- To investigate the causes of galactorrhea.
- To characterize drug-induced galactorrhea.
Main Methods:
- Retrospective study at a tertiary care center in South India.
- Included patients with galactorrhea or hyperprolactinemia from January 2017 to December 2017.
Main Results:
- 32 of 40 women had hyperprolactinemia-associated drug use (levosulpiride, domperidone, ranitidine, oral contraceptive pill, amisulpiride).
- Prokinetic use was the most common cause of galactorrhea.
- Other causes included idiopathic galactorrhea, idiopathic hyperprolactinemia, and prolactinoma.
Conclusions:
- Prokinetic use is the primary cause of galactorrhea in this cohort.
- Unnecessary investigations and D2 agonist treatments were common.
- Reduced non-specific prokinetic use and increased awareness are crucial.
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