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Cystic brain lesion in utero
Acta Pathologica Japonica
|April 1, 1986
Summary
Two autopsy cases revealed cystic brain lesions in utero, likely caused by circulatory disturbances. These findings highlight potential prenatal brain damage in infants with twin transfusion syndrome and thanatophoric dwarfism.
Area of Science:
- Neuropathology
- Fetal Medicine
- Perinatal Research
Background:
- Cystic brain lesions in utero are rare and can result from various insults.
- Understanding the etiology of these lesions is crucial for perinatal care and prognosis.
Observation:
- Autopsy of two fetuses revealed distinct cystic brain lesions.
- Case 1: Donor infant of twin transfusion syndrome with multicystic encephalomalacia in the anterior cerebral artery distribution.
- Case 2: Stillborn infant with thanatophoric dwarfism and chronic periventricular leukomalacia (PVL).
Findings:
- Both cases exhibited significant brain abnormalities suggestive of hypoxic-ischemic events.
- Multicystic encephalomalacia and chronic PVL were identified as the primary neuropathological findings.
Implications:
- Persistent circulatory disturbances in utero are proposed as the underlying cause for both conditions.
- These findings underscore the importance of monitoring fetal circulation and considering potential brain injury in high-risk pregnancies.