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Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function
Yongfeng Song1,2, Shan Lu3, Jiajun Zhao1
1Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, China.
Nuclear Receptor Research
|August 28, 2018
Summary
Small heterodimer partner (SHP) is a nuclear receptor that regulates gene expression. Recent findings show SHP critically controls non-coding RNA (ncRNA) expression and function, impacting cellular processes.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Small heterodimer partner (SHP, NR0B2) is an orphan nuclear receptor functioning as a transcriptional repressor.
- SHP influences physiological processes and diseases by regulating gene expression.
- Non-coding RNAs (ncRNAs), including lncRNAs and miRNAs, are key regulators of eukaryotic gene expression.
Purpose of the Study:
- To review recent findings on the role of SHP in regulating ncRNA expression and function.
- To highlight SHP's significance as a transcriptional regulator of ncRNAs.
Main Methods:
- Literature review of recent research.
- Analysis of studies investigating SHP's interaction with ncRNA biogenesis and function.
Main Results:
- SHP acts as a critical transcriptional regulator of ncRNAs.
- SHP influences the expression and function of various ncRNAs.
- These regulatory roles are implicated in diverse cellular processes.
Conclusions:
- SHP plays a vital role in the transcriptional regulation of ncRNAs.
- Understanding SHP's function in ncRNA regulation offers insights into cellular processes and disease mechanisms.
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