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The Nuclear Receptor Field: A Historical Overview and Future Challenges
Gisela I Mazaira1, Nadia R Zgajnar2, Cecilia M Lotufo2
1Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (1428), Argentina.
Nuclear Receptor Research
|August 28, 2018
Summary
This review covers the discovery of nuclear receptors, their structure, and function. It highlights the role of heat shock protein 90 (Hsp90) and orphan receptors, discussing future research directions.
Area of Science:
- Molecular Biology
- Endocrinology
- Biochemistry
Background:
- Nuclear receptors are crucial regulators of gene expression.
- Their discovery has revolutionized our understanding of cellular processes.
- Ligand-binding macromolecules and their isoforms play key roles.
Purpose of the Study:
- To summarize the historical development of nuclear receptor research.
- To detail the structural and functional properties of nuclear receptors.
- To discuss orphan receptors and future research challenges.
Main Methods:
- Review of seminal discoveries and research findings.
- Analysis of the structural basis of nuclear receptor function.
- Exploration of the Hsp90-based heterocomplex.
Main Results:
- Elucidation of the three-domain structure of nuclear receptors.
- Characterization of untransformed and transformed isoforms.
- Understanding the role of Hsp90 in receptor complex formation and function.
- Overview of orphan receptors and their significance.
Conclusions:
- Nuclear receptors are a complex family with diverse functions.
- The Hsp90 heterocomplex is essential for receptor activity.
- Further research into nuclear receptor mechanisms is warranted.
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