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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

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Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Dec 31, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
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Alopecia syphilitica.

Hsiu-Hui Chiu1, Chieh-Shan Wu2,3

  • 1Department of Dermatology, Pingtung Christian Hospital, Pingtung, Taiwan.

Indian Journal of Sexually Transmitted Diseases and AIDS
|August 28, 2018
PubMed
Summary
This summary is machine-generated.

Alopecia syphilitica, a rare symptom of secondary syphilis, can appear as the sole sign of infection. This case highlights essential syphilitic alopecia, emphasizing its importance for diagnosing syphilis in sexually active individuals.

Keywords:
Alopeciaalopecia syphiliticasecondary syphilis

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Syphilology

Background:

  • Alopecia syphilitica is an uncommon presentation of secondary syphilis.
  • It may accompany other mucocutaneous signs or be the sole manifestation.
  • Essential syphilitic alopecia is a rare, isolated form of this condition.

Purpose of the Study:

  • To present a case of essential syphilitic alopecia.
  • To raise physician awareness of this specific syphilitic manifestation.
  • To underscore the importance of considering syphilis in patients with unexplained alopecia.

Main Methods:

  • Case report presentation.
  • Review of clinical presentation and diagnostic considerations.
  • Emphasis on patient history and risk factors.

Main Results:

  • The case illustrates essential syphilitic alopecia as the primary symptom.
  • Highlights the diagnostic challenge when alopecia is isolated.
  • Reinforces the link between alopecia and secondary syphilis.

Conclusions:

  • Essential syphilitic alopecia requires high clinical suspicion.
  • Physicians should consider syphilis in sexually active patients presenting with alopecia.
  • Early diagnosis and treatment of syphilis are crucial to prevent complications.