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Updated: Feb 6, 2026

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
[INITIAL EXPERIENCE WITH TOPICAL NEGATIVE PRESSURE THERAPY IN THE TREATMENT OF PEDIATRIC BURNS]
Insights
Topical negative pressure (TNP) therapy effectively conditioned wounds and secured skin grafts in pediatric burn patients. This method showed an 86% graft take rate, proving useful for burns up to 30% total body surface area.
Area of Science:
- Pediatric surgery
- Burn management
- Wound healing technologies
Background:
- Pediatric burns present unique treatment challenges.
- Effective wound bed preparation and graft fixation are crucial for optimal outcomes.
- Topical negative pressure (TNP) therapy is an evolving treatment modality.
Purpose of the Study:
- To evaluate the experience of using topical negative pressure (TNP) therapy in treating pediatric burn injuries.
- To assess TNP's efficacy in wound bed conditioning and skin graft fixation.
- To determine the success rate of skin grafts applied using TNP in pediatric patients.
Main Methods:
- Retrospective analysis of eight pediatric burn patients treated over 20 months.
- Application of TNP for wound bed conditioning and/or skin graft fixation.
- Evaluation of average skin graft take rate eight days post-surgery.
Main Results:
- TNP was utilized in children aged 1.5 to 10 years with burn areas from 3% to 30% total body surface area.
- An average skin graft take of 86% was observed eight days after surgery.
- TNP demonstrated effectiveness in both wound bed preparation and graft stabilization.
Conclusions:
- Topical negative pressure (TNP) therapy is a valuable tool in managing pediatric burns.
- TNP facilitates effective wound bed conditioning and provides reliable skin graft fixation.
- The benefits of TNP in pediatric burn care are significant for injuries not exceeding 30% total body surface area.
Abstract:
We are presenting the experience of the Referral Centre for Pediatric Traumatism of the Croatian Ministry of Health in the usage of topical negative pressure therapy (TNP) method for the treatment of pediatric burns. In the period of 20 months we have used negative pressure wound therapy method in eight children aged between 1.5 and 10 years. Burn injuries total body surface area ranged between 3% and 30%. TNP was used either for the wound bed conditioning or for the fixation of skin grafts. Average skin graft „take” was 86% eight days after surgery according to the evaluation by the senior author. Based on our initial experience, we can confirm that TNP is a very useful tool which enables good wound bed conditioning as well as a good fixation tool for skin grafts if the burned area does not exceed 30% of total body surface area.
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