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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
12.4K

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Related Experiment Video

Updated: Feb 6, 2026

Electrochemiluminescence Assays for Human Islet Autoantibodies
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Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

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An update on autoantibodies in scleroderma.

Christopher A Mecoli1, Livia Casciola-Rosen

  • 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Current Opinion in Rheumatology
|August 28, 2018
PubMed
Summary

Recent studies reveal novel autoantibodies in scleroderma, offering insights into disease mechanisms and potential links between cancer and scleroderma. These findings highlight autoantibodies as crucial research tools.

Area of Science:

  • Immunology
  • Rheumatology
  • Autoimmunity

Background:

  • Scleroderma is associated with a growing number of autoantibodies.
  • Some autoantibodies may play a functional role in disease pathogenesis, contributing to vascular and fibrotic changes.
  • Emerging research explores the connection between malignancy and the onset of scleroderma.

Purpose of the Study:

  • To review recent findings on antibody specificities in scleroderma.
  • To update on insights into disease mechanisms provided by these antibodies.
  • To highlight the utility of autoantibodies as research probes.

Main Methods:

  • Literature review of recent research on scleroderma autoantibodies.
  • Analysis of studies investigating antibody-disease associations.

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  • Synthesis of findings on functional antibodies and the cancer-scleroderma relationship.

    • Main Results:

    • Discovery of novel autoantibodies in scleroderma patients with unique clinical associations.
    • Evidence suggesting that certain autoantibodies contribute to disease pathogenesis.
    • New insights into the relationship between cancer and scleroderma onset.

    Conclusions:

    • Advances in studying scleroderma antibody specificities enhance understanding of disease pathogenesis.
    • Newly described specificities and functional antibodies are key findings.
    • The emerging understanding of the cancer-scleroderma relationship is significant.