Related Experiment Video
Updated: Feb 6, 2026
08:10
Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
Published on: December 14, 2019
11.7K
Can infected pancreatic necrosis really be managed conservatively?
Bilal Al-Sarireh1, Nicholas G Mowbray, Ali Al-Sarira
1Department of General Surgery, ABM University Health Board, Swansea, UK.
European Journal of Gastroenterology & Hepatology
|August 28, 2018
Summary
Antibiotics alone can effectively treat infected pancreatic necrosis (IPN) in select stable patients, avoiding surgery and reducing complications like pancreatic insufficiency. This conservative approach offers a viable alternative to invasive procedures.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Infectious Disease Management
Background:
- Current guidelines favor minimally invasive drainage over open surgery for infected pancreatic necrosis (IPN).
- The study explores extending conservative management further with an antibiotics-only protocol for IPN.
Purpose of the Study:
- To evaluate the efficacy of an antibiotics-only protocol for treating infected pancreatic necrosis (IPN).
- To compare outcomes of antibiotic-only treatment with minimal access retroperitoneal pancreatic necrosectomy (MARPN).
Main Methods:
- A retrospective analysis of 33 patients with IPN treated with carbapenem antibiotics for at least 6 weeks.
- Comparison with 44 patients who underwent MARPN for IPN.
Main Results:
- The antibiotics-only group had no disease-specific mortality and one case of pancreatic insufficiency.
- The MARPN group experienced 20% mortality and 81.8% pancreatic insufficiency.
- Antibiotic-treated patients had lower severity scores and better inflammatory markers.
Conclusions:
- Antibiotics-only treatment is a valid option for hemodynamically stable IPN patients with less severe disease.
- Careful patient selection by experienced clinicians is crucial for successful conservative management of IPN.
Related Concept Videos
01:16Necrosis
6.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.6K
01:57What is Conservation Biology?
24.4K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.4K
01:30Acute Pancreatitis II: Clinical Manifestations and Management
877
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
877
02:04Conservation of Small Populations
17.4K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.4K
01:49Conserved Binding Sites
5.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.2K
01:17Urinary Tract Infection IV: Nursing Management
483
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
483