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Aspergillus Osteomyelitis of Clivus
Xiang Yang1, Yuekang Zhang1, Qiuyang Jing2
1Department of Neurosurgery, West China Hospital, Sichuan University Chengdu, P. R. China.
Abstract:
A 64-year-old man presented with a 2-month history of headache. The patient had a history of 30 years of diabetes. Magnetic resonance imaging revealed a lesion involving the sphenoid sinus and clivus. Surgery was performed through a transsphenoidal approach. Pathology suggested the diagnosis of the presence of Aspergillus. The patient received voriconazole treatment for 8 weeks, and 3-month follow-up demonstrated no progression. Aspergillus osteomyelitis of the skull base is uncommon, and accurate preoperative diagnosis is difficult. However, when there is a clear history of diabetes, a diagnosis of fungal osteomyelitis should be considered.
Insights
This case study highlights Aspergillus osteomyelitis of the skull base, a rare fungal infection. Early consideration in diabetic patients with persistent headaches is crucial for timely diagnosis and treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Otolaryngology
Background:
- Skull base osteomyelitis is rare, particularly fungal infections.
- Aspergillus species are opportunistic pathogens.
- Diabetes mellitus is a significant risk factor for fungal infections.
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