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[Neuroendocrine response to anesthesia with isoflurane]
Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1986
Summary
Isoflurane, a new anesthetic, did not prevent stress hormone increases during surgery. This study found elevated prolactin (PRL), cortisol, and thyroxine (T4) levels, similar to other agents.
Area of Science:
- Anesthesiology
- Endocrinology
Background:
- The hypothalamo-hypophyseal-thyroid-suprarenal axis is sensitive to surgical stress.
- Evaluating new anesthetic agents for their impact on endocrine stress responses is crucial for patient safety.
Purpose of the Study:
- To investigate the effects of the novel halogenated volatile anesthetic, isoflurane, on the hypothalamo-hypophyseal-thyroid-suprarenal axis during surgery.
- To determine if isoflurane offers superior protection against surgical and anesthetic stress compared to existing agents.
Main Methods:
- A study involving 16 young, healthy (ASA I) patients undergoing appendectomy.
- Blood samples were collected pre-operatively and intra-operatively to measure plasma levels of ACTH, cortisol, TSH, T3, T4, and PRL.
Main Results:
- A significant increase in plasma levels of prolactin (PRL), cortisol, and thyroxine (T4) was observed.
- These hormonal elevations were particularly pronounced towards the end of the surgical procedure.
Conclusions:
- Isoflurane, similar to enflurane, does not attenuate the typical surgical increase in PRL, cortisol, and T4.
- The findings suggest isoflurane does not provide enhanced protection against the endocrine stress response during surgery.