Related Experiment Video
Updated: Feb 6, 2026
10:13
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
14.2K
Proposal for a hierarchical, multidimensional, and multivariate approach to investigate cognitive aging
Alejandra Machado1, José Barroso2, Yaiza Molina3
1Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Psychology, Psychobiology and Methodology, Faculty of Psychology, La Laguna, Tenerife, Spain.
Neurobiology of Aging
|August 28, 2018
Summary
This study used novel statistical models to analyze cognitive aging in 460 adults. Findings reveal age is strongly linked to brain structure and cognitive function, particularly visual memory.
Area of Science:
- Neuroscience
- Gerontology
- Biostatistics
Background:
- Cognitive aging is a complex process influenced by multiple factors.
- Understanding the interplay between aging, brain structure, and cognitive function is crucial.
Purpose of the Study:
- To investigate cognitive aging using a multidimensional, hierarchical, and multivariate statistical approach.
- To analyze the simultaneous associations between age and demographic, clinical, cognitive, and neuroimaging measures.
Main Methods:
- Application of Orthogonal Partial Least Squares to Latent Structures (OPLS) and hierarchical models for cognitive aging research.
- Simultaneous analysis of 316 measures in 460 cognitively normal individuals aged 35-85 years.
Main Results:
- Age demonstrated a strong association with brain structure, particularly cortical thickness in frontal and parietal regions.
- Cognitive function showed a significant association with age, with visual memory being more strongly affected than executive functions or processing speed.
- Clinical measures exhibited weaker associations with age compared to neuroimaging and cognitive data.
Conclusions:
- OPLS and hierarchical models offer a promising approach to dissecting the complexity of cognitive aging.
- The study highlights a neuroimaging-cognitive-clinical hierarchy in the association with aging.
More Related Videos
Related Concept Videos
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
01:26Aging
713
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
713
01:19The Effect of Aging on Tissues
3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
01:23Cognition and Behavior
377
Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
377
01:21Cognitive Learning
1.2K
Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
1.2K
01:27Language and Cognition
802
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
802