Irisin response to downhill running exercise in humans
Journal of Exercise Nutrition & Biochemistry
|August 28, 2018
Summary
Downhill running (DHR), causing more muscle damage, significantly elevated irisin levels compared to level running (LR) over a 3-hour post-exercise period. This suggests DHR enhances irisin response more than LR, despite similar exercise intensity.
Area of Science:
- Exercise Physiology
- Endocrinology
- Muscle Biology
Background:
- Irisin is a myokine with potential roles in metabolism and muscle adaptation.
- Exercise-induced muscle damage (EIMD) is known to elicit various physiological responses.
- Understanding irisin's response to different exercise modalities is crucial for optimizing training and recovery.
Purpose of the Study:
- To investigate the differential effects of level running (LR) and downhill running (DHR) on irisin responses.
- To compare irisin levels following exercise protocols designed to induce varying degrees of muscle damage under matched oxygen consumption (VO2) and duration.
Main Methods:
- Fifteen healthy males were divided into LR (0% gradient) and DHR (-10% gradient) groups.
- Both groups performed 30 minutes of treadmill running at 70% of VO2max.
- Blood samples were collected pre-exercise and at 1, 3, and 24 hours post-exercise.
Main Results:
- While overall plasma irisin concentration changes over time did not differ significantly between groups, the area under the curve (AUC) for irisin was significantly higher in the DHR group (239,197 ng/mL) versus the LR group (92,293 ng/mL) over 3 hours post-exercise.
- Biomarkers of muscle damage and stress, including blood lactate, serum cortisol, myoglobin, and interleukin-6, were significantly elevated post-exercise in the DHR group compared to the LR group.
Conclusions:
- Downhill running, characterized by greater exercise-induced muscle damage, stimulates a more pronounced increase in circulating irisin compared to level running.
- These findings highlight the role of muscle damage intensity in modulating exercise-induced irisin release.
Keywords:
Irisin
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