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Updated: Feb 6, 2026

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization
Published on: September 1, 2018
Endometrial Stromal Sarcomas: A Revision of Their Potential as Targets for Immunotherapy
Sandra Tuyaerts1,2, Frédéric Amant3,4,5,6
1Division of Gynecologic Oncology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. sandra.tuyaerts@kuleuven.be.
Abstract:
Endometrial stromal sarcomas are a subtype of uterine sarcomas that are characterized by recurrent chromosomal translocations, resulting in the expression of tumor-specific fusion proteins that contribute to their tumorigenicity. These characteristics make the translocation breakpoints promising targets for immunotherapeutic approaches. In this review, we first describe the current knowledge about the classification of endometrial stromal sarcomas, and their molecular and genetic characteristics. Next, we summarize the available data on the use of translocation breakpoints as immunotherapeutic targets. Finally, we propose a roadmap to evaluate the feasibility of immunologic targeting of the endometrial stromal sarcoma-specific translocations in patients with recurrent disease.
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