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A Fresh View on Lymph Node Organogenesis

Lucas Onder1, Burkhard Ludewig1

  • 1Institute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, St. Gallen, Switzerland.

Trends in Immunology
|August 29, 2018
PubMed

Lymph nodes (LNs) are strategically positioned outposts of the immune system that underpin regional immune surveillance. The current model describing LN formation in mice is based on a two cell-type interaction scheme with lymphoid tissue inducer cells regulating the activation of mesenchymal lymphoid tissue organizer cells. We highlight here the key role of lymphatic endothelial cells during the initiation of LN formation. The involvement of lymphatic endothelial cells as an additional organizer cell type in LN organogenesis unveils multiple control levels that govern the generation of lymphoid organs. Moreover, the linkage between lymphangiogenic and lymphvasculogenic processes and guidance of the accumulation and activation of lymphoid tissue inducer cells in the embryo suggests that LN formation may be driven on demand by developing organ systems.

Keywords:
developmentfibroblastic reticular cellsinnate lymphoid cellslymphatic endothelial cellslymphoid tissue inducer cellssecondary lymphoid organsstromal cells

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