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Ocular findings and blood flow in patients with Takayasu arteritis: a cross-sectional study

Fehim Esen1, Rabia Ergelen2, Fatma Alibaz-Öner3

  • 1Department of Ophthalmology, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey fehimesen@yahoo.com.

The British Journal of Ophthalmology
|August 29, 2018
PubMed

Insights

Takayasu arteritis (TAK) patients show reduced ocular blood flow, particularly in the ophthalmic artery and central retinal artery. Radial artery pulselessness may indicate decreased ocular perfusion in TAK.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Vascular Medicine

Background:

  • Takayasu arteritis (TAK) is a chronic granulomatous vasculitis affecting large arteries.
  • Ocular complications, including ischemic events, can arise from TAK.
  • Understanding ocular blood flow in TAK is crucial for managing visual health.

Purpose of the Study:

  • To document ocular complications in TAK patients.
  • To evaluate ocular blood flow using Doppler ultrasonography.
  • To correlate ocular findings with systemic clinical features of TAK.

Main Methods:

  • Included 65 TAK patients and 30 healthy controls.
  • Conducted detailed rheumatological and ophthalmological evaluations.
  • Assessed ocular blood flow in the ophthalmic artery (OA) and central retinal artery (CRA) via color Doppler ultrasonography.

Main Results:

  • Hypertensive retinopathy (33.9%) and Takayasu retinopathy (6.2%) were observed.
  • No patients experienced permanent visual loss from ischemic or neovascular complications.
  • TAK patients exhibited increased resistivity index (RI) in OA (p=0.002) and CRA (p=0.001).
  • Radial artery pulselessness correlated with higher OA RI (p=0.031).

Conclusions:

  • This study reports a low prevalence of Takayasu retinopathy and no permanent visual loss.
  • Radial artery pulselessness is a novel predictor of reduced ipsilateral ocular perfusion.
  • Improved TAK management may be contributing to decreased ocular complication rates.
Abstract

Keywords:
Diagnostic tests/InvestigationImagingImmunologyRetina

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