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Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Statin-induced myopathy prevented by creatine administration
Maurizio Balestrino1,2, Enrico Adriano1
1Clinica Neurologica, Università degli Studi di Genova, Dipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili (DINOGMI), Genova, Italy.
BMJ Case Reports
|August 29, 2018
Summary
This case study suggests creatine may prevent statin-induced myopathy. Supplementing with creatine allowed a patient to tolerate simvastatin, resolving muscle pain and normalizing creatine kinase levels.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- A 66-year-old woman with chronic myeloid leukemia experienced amaurosis fugax due to carotid stenosis.
- Her initial serum cholesterol was significantly elevated (316 mg/dL, LDL 213 mg/dL).
Observation:
- The patient developed statin-induced myopathy (muscle pain, elevated creatine kinase) while on atorvastatin and later simvastatin.
- These adverse effects resolved upon discontinuation of statins.
- The patient experienced recurrent myopathy with simvastatin, necessitating its cessation.
Findings:
- Co-administration of creatine with simvastatin successfully resolved myopathy symptoms and normalized creatine kinase levels.
- Serum cholesterol levels were effectively managed with simvastatin and creatine supplementation.
Implications:
- Creatine may be a viable option to prevent or manage statin-induced myopathy, enabling continued statin therapy.
- This finding could inform treatment strategies for hyperlipidemia in patients susceptible to statin-related side effects.
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