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Endothelial Lipase Gene Polymorphism (584 C/T) in Coronary Artery Patients Among a Turkish Population
Levent Akman Solim1, Izgi Ayçil Gencan2, Behiç Çelik2
1Faculty of Medicine, Yeditepe University, Istanbul, Turkey leventsolim@gmail.com.
Background/Aim:
The endothelial lipase gene (LIPG) has a major role in regulating high density lipoprotein cholesterol (HDL-C), therefore this study investigated whether LIPG is associated with coronary artery disease (CAD) in a Turkish population.
Materials And Methods:
The LIPG (584 C/T) mutation was analyzed in 74 CAD patients and 73 controls.
Results:
There was a significant difference between the two groups regarding the mutant T allele frequencies (χ2=0.456, p=0.020; 26.7% and 41.8% in patient and control groups, respectively) for 584 C/T. Even though the TT genotype was not significantly different, it had p=0.054 which supported our results.
Conclusion:
The endothelial lipase gene (584 C/T) T allele might be protective in association with coronary artery disease. Therefore, LIPG gene is related to risk for CAD in the Turkish population probably through altering HDL-C metabolism.
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