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Peak of Standardized Uptake Value in Oral Cancer Predicts Survival Adjusting for Pathological Stage
Hidenori Suzuki1, Tsuneo Tamaki2, Masami Nishio3
1Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan hi.suzuki@aichi-cc.jp.
Background/Aim:
To predict survival outcomes of different patients with the same stage of disease is difficult. The possible correlation between 18F-fluorodeoxyglucose (18F-FDG) uptake parameters and survival outcomes was investigated in oral squamous cell carcinoma patients by multivariate analysis adjusted for the pathological stage according to the 8th edition of the tumor-node-metastasis (TNM) classification of the Union for International Cancer Contro.
Patients And Methods:
18F-FDG-uptake parameters of 28 patients were assessed by positron emission tomography with computed tomography (PET/CT).
Results:
A peak of standardized uptake value of primary tumor (p-SUVpeak) of ≥14.1 was significantly correlated with shorter overall survival by univariate and multivariate analyses adjusted for the pathological TNM stage. A p-SUVpeak of ≥14.1 was significantly associated with shorter local recurrence-free survival and disease-free survival.
Conclusion:
A higher p-SUVpeak on pretreatment 18F-FDG-PET/CT is a prognostic parameter of identifying lower survival outcomes.
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