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T790M Correlates with Longer Progression-free Survival in Non-small Cell Lung Carcinomas Harboring EGFR Mutations
Yoshihito Kogure1, Fumie Shigematsu2, Masahide Oki2
1Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan yo-kogure@umin.ac.jp.
Background/Aim:
The aim of this study was to evaluate the relationship between T790M status and the characteristics of non-small cell lung cancer (NSCLC) patients undergoing rebiopsy after initial epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy and whether the site of rebiopsy has an effect on the detection rate for T790M in these patients.
Materials And Methods:
We retrospectively reviewed the clinical data from stage IV or recurrent NSCLC patients who harbored EGFR mutations and who had initially received EGFR-TKI at our Center from January 2009 to December 2016.
Results:
Overall, 129 patients were included. The median age at EGFR-TKI therapy initiation was 73 years and 110 showed progressive disease. The presence of T790M mutation was associated with significantly longer progression-free survival (PFS) and EGFR mutation status. The participants' characteristics and rebiopsy site did not affect the T790M detection rate.
Conclusion:
It is highly recommended that patients with exon 19 deletions and long PFS undergo screening for T790M.
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