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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center

Nicolas Fazilleau1,2,3,4, Meryem Aloulou1,2,3,4

  • 1Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.

Frontiers in Immunology
|August 29, 2018
PubMed

An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a homogenous cell population dedicated to dampen the GC extent. Moreover, Tfr cells prevent autoimmunity since their dysregulation leads to production of self-reactive antibodies (Ab). However, a growing corpus of evidence has revealed additional and unexpected functions for Tfr cells in the regulation of B cell responses. This review provides an overview of the Tfr cell contribution and presents Tfr cell proprieties in the context of vaccination.

Keywords:
T follicular helper cellsT follicular regulatory cellsgerminal centersheterogeneitysubsets

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