Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

22.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.4K
What is Natural Selection?01:32

What is Natural Selection?

129.5K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.5K
Maturation of Endosomes01:28

Maturation of Endosomes

5.9K
The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
5.9K
Bacterial Protein Maturation01:26

Bacterial Protein Maturation

527
Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...
527
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.3K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.3K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation and analysis of 12,000 AI-driven CAR-T designs in the <i>Bits to Binders</i> competitions.

bioRxiv : the preprint server for biology·2026
Same author

Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression.

Nature biomedical engineering·2024
Same author

MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection.

Molecular immunology·2021
Same author

In Vivo Assessment of NK Cell-Mediated Cytotoxicity by Adoptively Transferred Splenocyte Rejection.

Methods in molecular biology (Clifton, N.J.)·2019
Same author

IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.

Frontiers in immunology·2018
Same author

A reliable scoring system after major liver resection in mice.

The Journal of surgical research·2016

Related Experiment Video

Updated: Feb 6, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.6K

Natural Killer Cells: Development, Maturation, and Clinical Utilization.

Alex M Abel1,2, Chao Yang1,2, Monica S Thakar1,3

  • 1Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, United States.

Frontiers in Immunology
|August 29, 2018
PubMed
Summary
This summary is machine-generated.

Natural killer (NK) cells are crucial for fighting tumors and viruses. Understanding their development and signaling pathways, including the role of various interleukins (ILs), enhances their clinical potential.

Keywords:
developmental stageseffector functionshumanmousenatural killer cells

More Related Videos

Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

1.9K

Related Experiment Videos

Last Updated: Feb 6, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.6K
Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

1.9K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Natural killer (NK) cells are key innate immune cells mediating anti-tumor and anti-viral responses.
  • NK cells distinguish self from non-self via inhibitory receptors, not clonotypic receptors.
  • Common gamma cytokines (IL-2, IL-7, IL-15) are vital for NK cell development.

Purpose of the Study:

  • To review recent advances in NK cell development and maturation.
  • To explore the emerging roles of pro-inflammatory cytokines (IL-12, IL-18, IL-27, IL-35) in NK cell priming.
  • To highlight the translational potential of NK cells in clinical applications.

Main Methods:

  • Literature review of recent studies on NK cell biology.
  • Analysis of signaling pathways and cytokine functions in NK cells.
  • Examination of genetic manipulation strategies for enhancing NK cell effector functions.

Main Results:

  • Established roles of common gamma cytokines in NK cell development.
  • Emerging understanding of pro-inflammatory cytokines' impact on NK cell transcriptional priming.
  • Identification of unique signaling pathways for NK cell genetic manipulation.

Conclusions:

  • NK cell biology shares characteristics with adaptive lymphocytes.
  • Further research into cytokine regulation and genetic manipulation can optimize NK cell therapies.
  • NK cells hold significant promise for clinical translation in cancer and infectious diseases.