Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Geometric Mean01:15

Geometric Mean

4.0K
The mean is a measure of the central tendency of a data set. In some data sets, the data is inherently multiplicative, and the arithmetic mean is not useful. For example, the human population multiplies with time, and so does the credit amount of financial investment, as the interest compounds over successive time intervals.
In cases of multiplicative data, the geometric mean is used for statistical analysis. First, the product of all the elements is taken. Then, if there are n elements in the...
4.0K
Geometric Sequences01:30

Geometric Sequences

286
In systems where values diminish by a constant proportion at each stage, the resulting sequence follows a geometric structure. Each new value in the sequence is obtained by applying a fixed multiplier to the preceding term. This regular, proportional decline type is often used to represent processes involving gradual loss, such as energy dissipation or reduction in amplitude over time.When analyzing the total effect of such a process across unlimited iterations, the series of values is referred...
286
Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

1.0K
In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
1.0K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

40.8K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
40.8K
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

22.1K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
22.1K
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

12.8K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
12.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pure stress formulation for modeling elastic waves using central finite differences.

The Journal of the Acoustical Society of America·2026
Same author

Ferroptosis and Wnt/β-Catenin Signaling Triggered by Environmentally Relevant Nanoscale Polypropylene Plastics in Human Intestinal Models.

ACS environmental Au·2026
Same author

Research on the efficacy of hybrid deep learning models for image-based classification of common oral conditions.

BMC oral health·2026
Same author

Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development.

The Journal of cell biology·2026
Same author

Identification of Key Targets of Herbal Compounds for Liver Fibrosis Using Network Pharmacology Combined With Transcriptomics.

Gastroenterology research and practice·2026
Same author

Oncology Health Management: From Educational Awareness to System Building.

Cancer innovation·2026
Same journal

Simple input-output dependencies explain neuronal activity.

Nature physics·2026
Same journal

Scaling and self-similarity in the formation of the embryonic epigenome.

Nature physics·2026
Same journal

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues.

Nature physics·2026
Same journal

The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport.

Nature physics·2026
Same journal

Squeezing, trisqueezing and quadsqueezing in a hybrid oscillator-spin system.

Nature physics·2026
Same journal

Noise-induced shallow circuits and the absence of barren plateaus.

Nature physics·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes
08:31

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes

Published on: September 13, 2018

10.4K

Geometric constraints during epithelial jamming.

Lior Atia1, Dapeng Bi2, Yasha Sharma1

  • 1Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

Nature Physics
|August 29, 2018
PubMed
Summary
This summary is machine-generated.

Cell shape and its variability are geometrically linked, not random noise. This relationship governs diverse biological processes, from embryo development to tissue repair, revealing universal principles of cell packing.

More Related Videos

Mammary Epithelial Transplant Procedure
08:51

Mammary Epithelial Transplant Procedure

Published on: June 10, 2010

31.7K
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

14.2K

Related Experiment Videos

Last Updated: Feb 6, 2026

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes
08:31

One-Step Approach to Fabricating Polydimethylsiloxane Microfluidic Channels of Different Geometric Sections by Sequential Wet Etching Processes

Published on: September 13, 2018

10.4K
Mammary Epithelial Transplant Procedure
08:51

Mammary Epithelial Transplant Procedure

Published on: June 10, 2010

31.7K
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

14.2K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biophysics

Background:

  • Epithelial cell shape changes are crucial in healing, embryonic development, and disease progression.
  • Cell-to-cell shape variability is often dismissed as biological noise rather than a studied phenomenon.

Purpose of the Study:

  • To investigate the underlying causes of cell shape and shape variability in epithelial tissues.
  • To determine if a universal principle governs cell shape and its variability across different biological systems.

Main Methods:

  • Analysis of epithelial cell shape and variability in diverse biological contexts, including human bronchial epithelial cells and Drosophila embryos.
  • Development of a mechanistic theory of cell-cell interactions to explain observed shape distributions.

Main Results:

  • A purely geometrical relationship was identified that mutually constrains cell shape and its variability.
  • Cell shape variability collapses into a common family of distributions across various epithelial systems.
  • A mechanistic theory demonstrates that increasing layer 'jamming' reduces cell elongation and variability.

Conclusions:

  • Cell shape and variability are governed by universal geometrical constraints, not solely by molecular events.
  • The findings suggest a fundamental connection between jamming phenomena in biological and inert systems.
  • Jamming behavior at larger scales may impose overriding geometrical constraints on cell packing and shape.