Related Experiment Video
Updated: Feb 6, 2026
02:36
Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation
Published on: March 8, 2024
1.7K
Microfluidics-based on-a-chip systems for isolating and analysing extracellular vesicles
Shang-Chun Guo1, Shi-Cong Tao2, Helen Dawn3
1Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Journal of Extracellular Vesicles
|August 29, 2018
Summary
Microfluidics technology offers advanced tools for studying extracellular vesicles (EVs), crucial for intercellular communication. These "on-a-chip" systems promise faster, more precise diagnostics and drug delivery, advancing personalized medicine.
Area of Science:
- Biotechnology
- Nanotechnology
- Cell Biology
Background:
- Extracellular vesicles (EVs) are vital for intercellular communication, carrying proteins and nucleic acids.
- EVs show potential as biomarkers for diagnosis/prognosis and as drug delivery systems (DDSs).
- Current EV research methods are time-consuming and low-throughput, necessitating better tools.
Purpose of the Study:
- To review advances in microfluidics-based technologies for extracellular vesicle (EV) research.
- To compare microfluidics with conventional EV isolation and analysis methods.
- To discuss the clinical potential of integrated "on-a-chip" systems.
Main Methods:
- Review of recent literature on microfluidics applications in EV isolation, detection, and analysis.
- Comparison of microfluidic techniques with traditional methods.
- Survey of integrated "on-a-chip" systems for EV analysis.
Main Results:
- Microfluidics offers low cost, low sample volume, high throughput, and precision for EV studies.
- "On-a-chip" systems are emerging for integrated EV analysis.
- These systems hold promise for "liquid biopsies" and DDS applications.
Conclusions:
- Microfluidics significantly improves EV research efficiency and capabilities.
- "On-a-chip" systems are paving the way for personalized and precision medicine.
- Future applications may include cloud-based, AI-integrated disease monitoring.
Related Concept Videos
01:19Cyclic Processes And Isolated Systems
3.5K
A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state.
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state.
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
3.5K
01:42The Extracellular Matrix
89.1K
Overview
89.1K
01:18Second Order systems II
409
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
409
01:21First Order Systems
431
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
431
01:20Second Order systems I
601
A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
By reinterpreting the system, one can derive the closed-loop transfer function, which...
601
02:36Chromatin Immunoprecipitation- ChIP
12.5K
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
12.5K