Related Experiment Video For adipocyte
Updated: Feb 6, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Possible role of vitamin D3 on the adipocyte/fibroblast trans-differentiation mediated by pancreas cancer
1Laboratory of Physiopathology of Obesity, University Laboratory of Medical Research-Department of Medicine, University of Verona, Italy.
Abstract:
In pancreatic tumors, white adipose tissue and metabolic disorders related to adipocytes, are recently reviewed as important co-factors in pancreas pathology. Cell differentiation in pancreatic cancer might involve therefore adipose tissue and factors released by adipocytes should play a fundamental role both in cancer onset and in its progression. Among these molecules, a great interest has been devoted quite recently to the hormonal role exerted by vitamin D3 in pancreatic cancer, particularly its active 1,25 dihydroxylated form. Despite the wide bulk of evidence reporting the chemopreventive role of vitamin D, the mechanism by which active vitamin D3 is able to counteract cancer progression and malignancy is yet far to be elucidated.
More Related Videos
10:31Robust Differentiation of Human iPSCs into a Pure Population of Adipocytes to Study Adipocyte-Associated Disorders
Published on: February 9, 2022
06:27A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies
Published on: August 8, 2019
Related Concept Videos
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Pancreas
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
Vitamins
Cells and Secretions of the Pancreas
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Introduction to Fibroblasts