Paget's Disease Mimicking Bone Metastasis in a Patient with Neuroendocrine Tumor on ⁶⁸Ga-DOTANOC PET/CT

Somatostatin (SST) is a neuropeptide present in neurons, endocrine cells, and a wide range of neuroendocrine tumors (NETs). ⁶⁸Ga-DOTATOC, ⁶⁸Ga-DOTANOC, and ⁶⁸Ga-DOTATATE are current SST analogues used for PET/CT which bind to SST receptors expressed in NETs. These SST analogues have been used successfully for diagnosis of SST-expressing tumors with a more sensitive detection technique than conventional scintigraphy. However, there is a lack of clinical data on the differentiation between NETs and other malignant tumors or benign pathological conditions. Here, we report a case of Paget's disease mimicking bone metastasis of NET on PET/CT due to increased ⁶⁸Ga-DOTANOC uptake and review examples of similar cases in the literature.