Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Humoral Immune Responses

Humoral Immune Responses

Responses to Drought and Flooding

Responses to Drought and Flooding

Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.

Responses to Salt Stress

Responses to Salt Stress

Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.

Responses to Heat and Cold Stress

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

Responses to Gravity and Touch

Responses to Gravity and Touch

Gravitropism: Plant Responses to Gravity

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synergistic hyperinflammation in IgA vasculitis complicated by varicella-induced HLH: a case report.

Frontiers in immunology·2026

Same author

A historical note: Rediscovering an unpublished response to Korn and Freidlin (2011).

Statistical methods in medical research·2026

Same author

Case Report: genotype-phenotype correlations in <i>FLNA</i> mutations: insights from a case of multisystem dysfunction.

Frontiers in genetics·2026

Same author

MaizeGEP: A Maize Hybrids Dataset with Genotype, Phenotype, and Envirotype to Develop Genomic Selection Models.

Genomics, proteomics & bioinformatics·2026

Same author

X-linked lymphoproliferative disease with initial onset of neurological symptoms: a case and literature review.

Frontiers in immunology·2025

Same author

Efficient randomized adaptive designs for multi-arm clinical trials.

Statistical methods in medical research·2025

Same journal

Impact of Information Leakage in Platform Trials With Survival Endpoints on Type I Error Control.

Pharmaceutical statistics·2026

Same journal

Harmonic Fowlkes-Mallows Index for Medical Diagnostics Tests and Optimal Cut-Off Point Selection of Binary Diseases.

Pharmaceutical statistics·2026

Same journal

Early Phase Dose-Finding Designs for CAR-T Cell Therapies.

Pharmaceutical statistics·2026

Same journal

Optimizing Randomization Ratios in Clinical Trials With Survival Endpoints.

Pharmaceutical statistics·2026

Same journal

CUI-MET: A Clinical Utility Index Based Analysis and Decision Framework for Dose Optimization in Multiple-Dose, Multiple-Outcome Randomized Trials.

Pharmaceutical statistics·2026

Same journal

Will the Pharmaceutical Industry Need Statisticians in an AI World?

Pharmaceutical statistics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 6, 2026

An Instrumented Pull Test to Characterize Postural Responses

An Instrumented Pull Test to Characterize Postural Responses

Published on: April 6, 2019

Nonparametric response-adaptive randomization for continuous responses.

Zhongqiang Liu^1,2, Feifang Hu³, Li-Xin Zhang¹

¹School of Mathematical Sciences, Zhejiang University, Hangzhou, China.

Pharmaceutical Statistics

|August 29, 2018

Summary

This summary is machine-generated.

This study introduces a novel response-adaptive randomization procedure using the Mann-Whitney U test. The new method is more robust and ethical for clinical trials compared to existing procedures.

Keywords:

Mann-Whitney U test allocation proportion function comparative probability ethics power

More Related Videos

Cell-Free Dot Blot as a Practical and Adaptable Immunoassay Platform for the Detection of Antibody Response in Human and Animal Sera

Cell-Free Dot Blot as a Practical and Adaptable Immunoassay Platform for the Detection of Antibody Response in Human and Animal Sera

Published on: May 23, 2025

Recording Light-evoked Postsynaptic Responses in Neurons in Dark-adapted, Mouse Retinal Slice Preparations Using Patch Clamp Techniques

Recording Light-evoked Postsynaptic Responses in Neurons in Dark-adapted, Mouse Retinal Slice Preparations Using Patch Clamp Techniques

Published on: February 11, 2015

Related Experiment Videos

Last Updated: Feb 6, 2026

An Instrumented Pull Test to Characterize Postural Responses

An Instrumented Pull Test to Characterize Postural Responses

Published on: April 6, 2019

Cell-Free Dot Blot as a Practical and Adaptable Immunoassay Platform for the Detection of Antibody Response in Human and Animal Sera

Cell-Free Dot Blot as a Practical and Adaptable Immunoassay Platform for the Detection of Antibody Response in Human and Animal Sera

Published on: May 23, 2025

Recording Light-evoked Postsynaptic Responses in Neurons in Dark-adapted, Mouse Retinal Slice Preparations Using Patch Clamp Techniques

Recording Light-evoked Postsynaptic Responses in Neurons in Dark-adapted, Mouse Retinal Slice Preparations Using Patch Clamp Techniques

Published on: February 11, 2015

Area of Science:

Biostatistics
Clinical Trial Design
Nonparametric Statistics

Background:

Response-adaptive randomization balances treatment arms based on accumulating data.
Existing methods often rely on parametric assumptions, limiting their applicability.
Nonparametric models are crucial for flexible and robust clinical trial analysis.

Purpose of the Study:

Propose a novel response-adaptive randomization procedure.
Develop a procedure applicable to nonparametric models.
Enhance ethical considerations and robustness in clinical trials.

Main Methods:

Utilized the Mann-Whitney U test statistic for response adaptation.
Derived asymptotic properties of the proposed randomization procedure.
Obtained power functions under the Mann-Whitney U test framework.

Main Results:

The proposed procedure demonstrates robustness and ethical advantages in simulations.
It offers a viable nonparametric alternative to existing methods.
Successful illustration in a redesigned real-world clinical trial.

Conclusions:

The Mann-Whitney U-based response-adaptive randomization is a valuable tool.
This nonparametric approach improves upon traditional parametric methods.
The procedure enhances efficiency and ethical conduct in clinical research.